Video: X-rays reveal dance of electrons!

Short animation I produced in collaboration with Design Science and Dr Adam Kirrander from the University of Edinburgh.

The piece explores work being conducted by Adam’s team which hopes to ‘freeze’ the rapid motion of electrons. The principles at play here are not dissimilar to those used in early high-speed photography, but in this case involves measuring how atoms diffract rapid pulses of x-rays. The technique is hoped to revolutionise the ways in which we study and understand chemical interactions, such as the breaking and formation of bonds.

This was my first full scale animation project and I learnt a lot in the production process – individual scenes were animated in Apple Motion and then exported and compiled in a FCPX timeline. There are lots of hand drawn elements within the piece, some of these were drawn on paper and scanned in – while others were drawn in photoshop with a graphics tablet – the leaves and eye at the end were drawn multiple times and then animated – that was a lot of fun!

There were some little touches that I found made a big difference visually, such as adding a subtle background texture and applying a faint vignette with blurring around the edges of the frame – this helped to draw attention to the centre.

The voice over was recorded on a Marantz PMD 661 with an AKG D230 – it wasn’t recorded in the best environment, so I had to work to tidy it up in Ableton Live. Subtle sound design also helped to bring a bit more depth to the animated scenes, this was also composed and produced in Ableton.

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Video: Structure and Order – A Century of Symmetry

Chemical crystallographer Judith Howard reflects on the beautiful aesthetics of crystallographic exploration and her career, including time spent with Nobel laureate Dorothy Hodgkin.

The end of the video provides links to some of the other videos in the crystallography collection!

Crystal Clear: Exploring Crystallography on Film

X-ray Crystallography – ever heard of it? Perhaps not, but it’s arguably one of the most important scientific breakthroughs of the 20th Century. Why? Well, it’s an incredibly powerful technique that allows us to look at really small things, like protein molecules or even DNA! Once we know how these molecules are assembled, we can begin to better understand how they work.

How does it work? Essentially you take your sample, crystallise it and then fire X-rays at it. You then measure the way in which the crystal scatters or diffracts the X-rays – the resulting ‘diffraction pattern’ is what you need (and a bit of maths) to work back to the structure of the molecules that make up the crystal. So in theory, as long as you can crystallise your sample – you should be able to work out the molecular structure!

To find out more watch this simple animation we recently published:

The technique was developed over 100 years ago and it has led to some incredibly important discoveries, including the structure of DNA – since it’s inception, work relating to Crystallography has been awarded 28 Nobel prizes. To mark the continuing success of Crystallography – we received funding from the STFC to produce a series of films that helped explain and celebrate this technique.

The above animation was scripted in house and animated by the awesome 12foot6 – it also features the voice of Stephen Curry, a structural biologist based at Imperial College London.

Understanding Crystallography

I produced and directed this two-part series, working with Elspeth Garman of Oxford University and Stephen Curry. The two pieces aim to explain how the technique works and what’s needed to grow your crystals and subject them to X-ray analysis. The films take us from a microbiology lab at the University of Oxford to the Diamond Light Source, a huge facility that hosts a particle accelerator designed to generate incredibly powerful beams of X-rays.

As always, the hardest part in producing these pieces was in deconstructing the explanation of what is a very complicated process… hopefully we pulled it off – see for yourself below!

Part 1 – why proteins need to be crystallised and how this is done.

Part 2 – what it takes to shine x-rays at your crystals and how we work back from diffraction patterns to determine structures.

Crystallography and beyond

Producer Thom Hoffman also worked on this project – he produced two pieces, one exploring the history of farther and son team who helped develop the technique

and the other looking at the application of this technique on the recent Curiosity Mars rover.